随着一氧化氮生理、生化、病理学、药理学等研究的深入,一氧化氮与帕金森病的关系日益受到关注。研究表明,一氧化氮本身以及通过参与1-甲基-4-苯基-1,2,3,6-四氢吡啶的神经毒性而导致黑质多巴胺神经元的损伤可能在帕金森病的发生机制中发挥重要的作用。本文综述了一氧化氮在帕金森病的发生发展及其治疗方面的进展。 With the deepening of the physiological, biochemical, pathological and pharmacological studies of nitric oxide, the relationship between nitric oxide and Parkinson’s disease has drawn increasing attention. Studies have shown that damage to substantia nigra dopamine neurons by nitric oxide alone and by the neurotoxicity involved in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine may be attributed to Parkinson’s disease Mechanism plays an important role. This article reviews the progress of nitric oxide in the development of Parkinson’s disease and its treatment.