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[目的]探讨动脉粥样硬化患者的C-反应蛋白(CRP)、低密度脂蛋白(LDL)及非酒精性脂肪肝的关系。[方法]选取我院2015年6月~2016年1月存在动脉粥样硬化的患者共56例,据炎症指标CRP水平分为2组,其中CRP正常(<10mg/L)的A组患者有30例,CRP异常(10~30mg/L)的B组患者26例,分析2组间脂质代谢的LDL水平及非酒精性脂肪肝的发生率。[结果]A组患者的LDL水平(3.18±0.82)mmol/L高于B组(1.86±0.75)mmol/L,但B组患者的非酒精性脂肪肝的发生率(73.07%)高于A组(40.00%)。[结论]慢性炎症介质可干扰胆固醇代谢,使血浆LDL下降,组织细胞内胆固醇集聚,可能加速肝脏脂肪变性;CRP异常动脉粥样硬化患者的血浆LDL不能反映其组织细胞内真实胆固醇水平,不能作为降脂依据,不能有效反映患者的风险程度;炎性递质可导致常规剂量下的他汀抵抗,CRP异常的动脉粥样硬化患者可能需要超强度他汀治疗。
[Objective] To investigate the relationship between C-reactive protein (CRP), low density lipoprotein (LDL) and non-alcoholic fatty liver in patients with atherosclerosis. [Methods] A total of 56 patients with atherosclerosis in our hospital from June 2015 to January 2016 were selected and divided into two groups according to the level of CRP. The patients in group A with normal CRP (<10 mg / L) had 30 patients with abnormal CRP (10 ~ 30mg / L), and 26 patients in group B. The LDL levels and the incidence of non-alcoholic fatty liver were analyzed. [Results] The LDL level in group A (3.18 ± 0.82) mmol / L was higher than that in group B (1.86 ± 0.75) mmol / L, but the incidence of non-alcoholic fatty liver in group B (73.07%) was higher than that in group A Group (40.00%). [Conclusion] Chronic inflammatory mediators may interfere with cholesterol metabolism, decrease plasma LDL and intracellular accumulation of cholesterol, which may accelerate hepatic steatosis. Plasma LDL in patients with CRP abnormal atherosclerosis can not reflect the true intracellular cholesterol level and can not be used as The basis for lipid lowering does not effectively reflect the patient’s risk level; inflammatory neurotransmitters lead to statin resistance at routine doses and atherosclerosis patients with abnormal CRP may require extra-statin therapy.