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本文应用双抗体夹心ＥＬＩＳＡ法对４５例单纯疱疹性角膜炎（ＨＳＫ）患者血清可溶性ＩＬ－２受体（ｓＩＬ－２Ｒ）进行了研究。结果显示，活动期ＨＳＫ患者血清ｓＩＬ－２Ｒ水平显著高于非活动期和正常对照组（Ｐ＜０．００１）；非活动期ＨＳＫ患者血清ｓＩＬ－２Ｒ水平与正常对照组相比无显著性差异（Ｐ＞０．０５）。通过对两种不同类型活动期ＨＳＫ患者血清ｓＩＬ－２Ｒ水平的比较，可见基质型明显高于上皮型（Ｐ＜０．０５）。提示，活动期ＨＳＫ患者血清ｓＩＬ－２Ｒ水平异常升高，导致机体免疫功能下降，抗病毒能力降低，这可能是ＨＳＫ反复发作的原因之一。此外，血清ｓＩＬ－２Ｒ水平的异常升高与ＨＳＫ病情有一定的相关性
In this paper, 45 cases of herpes simplex keratitis (HSK) patients with serum soluble IL-2 receptor (sIL-2R) were studied by double antibody sandwich ELISA. The results showed that serum sIL-2R levels in active HSK patients were significantly higher than inactive and normal controls (P <0.001); serum sIL-2R levels in inactive HSK patients compared with the normal control group had no significant difference (P> 0.05). By comparing the levels of serum sIL-2R in two types of active HSK patients, we found that the stromal type was significantly higher than that of epithelial type (P <0.05). These results suggest that abnormally elevated serum sIL-2R levels in active HSK patients lead to decreased immune function and antiviral ability, which may be one of the reasons for HSK recurrent episodes. In addition, abnormal levels of serum sIL-2R have some correlation with HSK