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目的 探讨健康指导及心理护理的联合应用对于老年糖尿病合并抑郁症患者的疗效。方法 将我院2018年2月至2019年2月收治的80例老年糖尿病且合并抑郁症患者，随机进行分组，每组40例。基础护理组患者进行常规的降糖药物用药护理、生活指导等，观察组在上述护理基础上给予患者健康指导及心理护理。比较两组的疗效、血糖控制达标时间、抑郁情绪缓解时间，护理前后的空腹血糖、餐后2h血糖，抑郁自评量表评分、糖尿病特异性生存质量量表评分。结果 观察组疗效高于基础护理组，P＜0.05。观察组空腹血糖、餐后2h血糖水平、抑郁自评量“,”Objective To explore the effect of combined application of health guidance and psychological nursing on elderly patients with diabetes mellitus complicated with depression. Methods Eighty elderly patients with diabetes mellitus complicated with depression from February 2018 to February 2019 were randomized into 40 patients in each group. The basic nursing group performed routine hypoglycemic medication care and life guidance for elderly patients with diabetes mellitus who were treated with depression， and the observation group implemented the above-mentioned basic nursing work for elderly diabetic patients with depression. Give patients health guidance and psychological care. Comparison of two groups of elderly patients with diabetes mellitus combined with depression; elderly patients with diabetes mellitus control time， depression relief time， fasting state before and after treatment blood glucose， 2 h postprandial blood glucose level， anxiety self-rating scale score， depression self-rating scale Score， diabetes-specific quality of life scale score.Results The nursing effect of elderly patients with diabetes and depression in the health guidance and psychological nursing group was higher than that in the basic nursing group， P＜0.05. The fasting state of blood glucose in the observation group， the blood glucose level at 2 hours after meal， the self-rating anxiety score， and the self-rating depression scale were lower than the basic nursing group， P＜0.05. The scores of the diabetes-specific quality of life scale in the observation group were higher than those in the basic care group， P＜0.05. In the observation group， the time of blood glucose control and the time of depression were lower than that of the basic nursing group， P＜0.05. Conclusion Elderly patients with diabetes and combined with depression in the implementation of basic nursing work， health guidance and psychological care， can better help patients to reduce bad mood and control blood sugar， improve patient quality of life.