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目的研究原发性高血压(EH)伴阻塞性睡眠呼吸暂停低通气综合征(OSAHS)与左心室结构改变的关系并分析其影响因素。方法对2004-07-2007-07住院的EH患者进行睡眠监测,并对其一般资料、生化指标、超声心动图检查结果进行分析,比较EH+OSAHS与EH患者间左心室构型的差异,观察其影响因素。结果EH+OSAHS组年龄、男性比例、体质量指数、收缩压、空腹及餐后2 h血糖均高于EH组(均P<0.01);EH+OSAHS组的左室舒张期内径、室间隔厚度、左室后壁厚度、左室质量指数、相对室壁厚度均高于EH组(均P<0.01);与左心室肥厚发生相关的危险因素为OSAHS、高血压病程、血压分级、糖尿病、肾功能不全。结论与EH相比,EH+OSAHS左心室构型改变更严重。
Objective To investigate the relationship between left ventricular structural changes and primary hypertension (EH) with obstructive sleep apnea-hypopnea syndrome (OSAHS) and to analyze its influencing factors. Methods Sleep monitoring was performed on hospitalized patients with EH from July 2004 to July 2007, and the general data, biochemical indexes and echocardiographic findings were analyzed. The differences of left ventricular configuration between EH + OSAHS and EH patients were observed and compared Its influencing factors. Results The age, male ratio, body mass index, systolic blood pressure, fasting and 2 h postprandial blood glucose in EH + OSAHS group were significantly higher than those in EH group (all P <0.01). The left ventricular diastolic dimension, , Left ventricular posterior wall thickness, left ventricular mass index and relative wall thickness were higher than those in EH group (all P <0.01). The risk factors of left ventricular hypertrophy were OSAHS, duration of hypertension, blood pressure classification, diabetes, Incomplete. Conclusions Compared with EH, left ventricular configuration of EH + OSAHS is more serious.