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本院研制的 38%氟化氨银溶液有抑龋、抑菌、治疗牙本质过敏等良好效果。为使临床医师了解其安全性 ,本文报告了有关急性毒性、对牙髓和口腔粘膜刺激性实验结果。用小白鼠进行急性毒性实验结果表明 ,38%氟化氨银的 LD50 为 32 7.93mg/ kg。用大白鼠进行牙髓和粘膜刺激性实验 ,仅发现涂擦药物后有一颗磨牙牙髓轻度充血 (即刻处死组 ) ;颊、舌粘膜涂擦药物后 ,仅个别标本出现粘膜下层轻度充血 (即刻处死组 ) ,3天及 7天处死组牙髓、粘膜均为正常。本研究结果表明临床使用氟化氨银是比较安全的
The hospital developed 38% of the ammonia fluoride solution has inhibition of caries, antibacterial, dentin hypersensitivity and other good results. In order for clinicians to understand their safety, this article reports experimental results on acute toxicity, irritation to the pulp and oral mucosa. The acute toxicity test in mice showed that the LD50 of 38% ammonium fluoride was 32.993 mg / kg. In rats and mucosa irritation experiments with rats, only a toothbrush was found to have mild hyperemia (immediate sacrifice group) after smearing the drug; mild mucosal submucosal hyperemia (Immediately sacrificed group), 3 days and 7 days sacrifice group dental pulp, mucous membrane are normal. The results of this study show that the clinical use of ammonium fluoride is more safe