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新近在有关生长调节剂的会议上,与会者对Cohen的研究天作倍加赞尝。Cohen不仅首先描述了两种组织特异性生长因子〔表皮生长因子(EGF)和神经生长因子(NGF)〕,而且还提纯了EGF,鉴定出它的受体及与EGF受体有联系的酪氨酸激酶的活性。Cohen还报告了EGF受体结合的特征及其依赖EGF的自身磷酸化作用,发现受体磷酸化部位不寻常的化学性质(磷酸基附着于酪氨酸残基上),以及受体促使其它蛋白质酪氨酸残基磷酸化的能力。这些发现为一组逆转录病毒肿瘤基因的基本功能提供了初步线索。现已弄清,实际上不仅几个病毒肿瘤基因编码酪氨酸激酶,而且还有至少一种肿
At a recent conference on growth regulators, participants praised Cohen’s research day. Cohen not only first described two tissue-specific growth factors, epidermal growth factor (EGF) and nerve growth factor (NGF), but also purified EGF to identify its receptor and Tyrosine, which is linked to the EGF receptor Acid kinase activity. Cohen also reported the characteristics of EGF receptor binding and its dependence on EGF’s autophosphorylation, which revealed unusual chemical properties of the phosphorylation site on the receptor (phosphate groups attached to tyrosine residues), as well as receptors that prompt other proteins Tyrosine residue phosphorylation ability. These findings provide initial clues to the basic function of a group of retroviral oncogenes. It is now clear that in fact not only several viral oncogenes encode tyrosine kinases, but also at least one swollen