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应用生物素-亲和素-酶系统(ABS)技术检测结核性脑膜炎(结脑)组及对照组脑脊液(CSF)中活性B细胞(ABL)和结核杆菌蛋白A60-IgG水平,并检测有关指标:如每立方毫升CSF中细胞总数、淋巴细胞数、ABL数及200个淋巴细胞中ABL的百分率。发现结脑组ABL阳性率为65.5%(21/32),非结核中枢神经系统(CNS)炎症组为60.0%(18/30),而非炎症性CNS疾患仅为13.3%(2/15);特异性抗体阳性率在结脑组为78.1%(25/32),对照组中1例化脓性脑膜炎(化脑)阳性。ABL在发病早期出现率较高,特异抗体稍后出现。每立方毫升CSF细胞数与淋巴细胞中ABL百分率在病程中存在正相关关系。这对结脑的早期诊断有一定的辅助作用。
The levels of ABL and A60-IgG in cerebrospinal fluid (CSF) of tuberculous meningitis (tuberculous meningitis) group and control group were detected by biotin-avidin-enzyme system (ABS) Indicators: such as the total number of cells, the number of lymphocytes, the number of ABL and the percentage of ABL in 200 lymphocytes per cubic milliliter of CSF. The positive rate of ABL was 65.5% (21/32) in tuberculosis group and 60.0% (18/30) in non-tuberculosis central nervous system (CNS) group and 13.3% (2/15) in non-inflammatory CNS group ; The positive rate of specific antibody was 78.1% (25/32) in the tuberculous meningitis group and 1 case of purulent meningitis (mesencephalic brain) in the control group. ABL appeared early in the incidence of higher specific antibodies appear later. There is a positive correlation between the number of CSF cells per cubic milliliter and the percentage of ABL in lymphocytes during the course of the disease. This early diagnosis of tuberculosis have some auxiliary role.