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目的了解溃疡性结肠炎患者出现骨质疏松的可能危险因素,为临床针对性早期干预提供方向。方法选取该院2012年1月-2014年12月收治的UC患者100例作为观察组,健康体检者60例作为对照组。测定2组骨密度,血钙、血磷、白蛋白、碱性磷酸酶(ALP)等生化指标,并与对照组进行比较。结果观察组患者的骨密度低于对照组,差异有统计学意义(P<0.05)。2组血钙、血磷、ALP及白蛋白比较差异无统计学意义(P>0.05)。观察组患者的血清白细胞介素-8(IL-8)、白细胞介素-6(IL-6)及肿瘤坏死因子(TNF-α)水平均高于对照组,差异均有统计学意义(P<0.05)。结论溃疡性结肠炎患者易患骨质疏松症,其相关危险因素与患者病情程度有关。
Objective To understand the possible risk factors for osteoporosis in patients with ulcerative colitis and provide direction for clinical targeted early intervention. Methods A total of 100 UC patients admitted from January 2012 to December 2014 in our hospital were selected as observation group and 60 healthy subjects as control group. The bone mineral density, serum calcium, serum phosphorus, albumin, alkaline phosphatase (ALP) and other biochemical parameters were measured and compared with the control group. Results The BMD of the observation group was lower than that of the control group, with significant difference (P <0.05). There was no significant difference in serum calcium, serum phosphorus, ALP and albumin between the two groups (P> 0.05). The levels of serum IL-8, IL-6 and TNF-α in the observation group were significantly higher than those in the control group (P <0.05). Conclusions Patients with ulcerative colitis are predisposed to osteoporosis. The related risk factors are related to the severity of the disease.