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采用新西兰家兔３５只，随机分４组，分别观察了向侧脑室注射生理盐水（ＮＳ）、白介素１β、白介素１β＋α－黑素细胞刺激素和α－黑素细胞刺激素对家兔结肠温度及脑腹中隔区精氨酸加压素（ＡＶＰ）含量的影响。结果发现，正常家兔侧脑室注射α－黑素细胞刺激素，引起脑腹中隔区ＡＶＰ含量明显增加，但并不影响家兔结肠温度；侧脑室注射白介素１β引起家兔结肠温度明显上升（Ｐ＜０００１），但腹中膈区ＡＶＰ升高并不明显（Ｐ＞００５）；侧脑室注射白介素１β后１５ｍｉｎ再注射α－黑素细胞刺激素，明显抑制家兔结肠温度上升，同时脑腹中膈区ＡＶＰ含量显著增加（Ｐ＜００５）。提示脑腹中隔区ＡＶＰ增多可能参与了α－黑素细胞刺激素解热作用的中枢机制，α－黑素细胞刺激素可能是发热时脑腹中隔区ＡＶＰ增多的一个重要因素。
A total of 35 New Zealand rabbits were randomly divided into 4 groups. The effects of injection of NS, IL-1β, IL-1β + α-melanocyte-stimulating hormone and α-melanocyte-stimulating hormone on the colonic temperature and Effect of arginine vasopressin (AVP) in the ventral septal area of the brain. The results showed that injection of α-melanocyte stimulating hormone into the lateral ventricle of normal rabbits caused a significant increase of AVP content in the ventral septal area of rabbits, but did not affect the colonic temperature in rabbits. The injection of interleukin-1β into the intracerebroventricular injection induced a significant increase in colonic temperature P <0001), but AVP increased in the diaphragmatic area was not significant (P> 0.05); injection of α-melanocyte stimulating hormone 15 min after intracerebroventricular injection of IL-1β significantly inhibited the increase of colonic temperature in rabbits , Meanwhile, AVP content in brain diaphragm area increased significantly (P <005). Suggesting that increased AVP in the septal area may be involved in the central mechanism of anti-pyretic effects of α-melanocyte-stimulating hormone. Α-melanocyte stimulating hormone may be an important factor in the increase of AVP in the ventral septal area upon fever.