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目的 :研究血链球菌 A19培养上清液对脑膜炎球菌的定量抑菌作用。方法 :将血链球菌 A19培养上清液抽滤除菌 ,加入含一定浓度脑膜炎球菌培养液 37℃作用 2 4、48、72小时后分别进行活菌计数。结果 :作用 2 4小时后对照组细菌数增加 ,而试验组细菌数减少 ,抑菌率为 98.93% ;48小时后为 84.10 % ;72小时后为 6 6 .6 7% ;结论 :血链球菌 A19对脑膜炎球菌的抑菌作用是由于其代谢产物中含有抑菌成分 ,若提纯此成分有可能用于抑制脑膜炎球菌感染
Objective: To study the quantitative antibacterial activity of Streptococcus sanguisin A19 on meningococcus. Methods: Streptococcus sobrinus A19 culture supernatant was suction-sterilized and added with a certain concentration of meningococcal culture medium at 37 ℃ for 2, 44 and 72 hours respectively for viable count. Results: After 24 hours, the number of bacteria in the control group increased, while the number of bacteria in the experimental group decreased, the antibacterial rate was 98.93%, 84.10% after 48 hours and 66.76% after 72 hours.Conclusion: Streptococcus sanguis The bacteriostatic action of A19 against meningococci is due to the fact that their metabolites contain bacteriostatic components which may be used to inhibit meningococcal infection