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目的探讨Lambert-Eaton综合征的临床特点。方法回顾11例Lambert-Eaton综合征患者的临床资料,并加以讨论分析。结果该病的临床特点为肌无力下肢重于上肢,近端重于远端,腱反射常减弱或消失。神经重复频率刺激低频刺激时波幅递减,高频刺激时波幅递增达100%以上,有诊断意义。结论本病临床表现特异性不强,误诊率高,早期诊断并及时治疗具有重要意义。
Objective To investigate the clinical features of Lambert-Eaton syndrome. Methods The clinical data of 11 patients with Lambert-Eaton syndrome were retrospectively analyzed and discussed. Results The clinical features of the disease were myasthenia gravis, lower extremities heavier than the upper extremities, proximal heavier distal extremities, and tendon reflexes weakened or disappeared. Nerve repetitive frequency stimulated low-frequency stimulation amplitude decreases, high-frequency stimulation wave amplitude increased by more than 100%, a diagnostic significance. Conclusion The clinical manifestations of this disease is not strong, high misdiagnosis rate, early diagnosis and prompt treatment is of great significance.