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目的:探讨CD68+巨噬细胞在胃癌组织中的浸润分布与临床病理特征及预后的相关性。方法:免疫组化染色检测CD68在58例根治性手术切除胃腺癌组织中的表达情况,并分析CD68+巨噬细胞的浸润分布与患者临床病理特征和预后的相关性。结果:CD68+巨噬细胞在胃癌组织中的浸润数量与病理分级(P=0.006)、淋巴结转移(P=0.002)和TNM分期(P=0.040)相关,与性别、年龄、肿瘤部位和肿瘤最大径未见明显相关性;多因素分析显示肿瘤最大径(P=0.024,HR 3.347,95%CI 1.497-9.918)、TNM分期(P=0.019,HR 2.891,95%CI 1.177-7.969)和CD68表达(P=0.034,HR 2.598,95%CI 0.887-7.912)是胃癌独立的预后因素;生存曲线提示CD68+巨噬细胞低度浸润的胃癌患者预后较好(P=0.011)。结论:CD68+巨噬细胞在胃癌组织中的浸润及分布有重要临床意义,CD68表达跟胃癌患者预后呈负相关。
Objective: To investigate the relationship between the infiltration and distribution of CD68 + macrophages in gastric carcinoma and their clinicopathological features and prognosis. Methods: Immunohistochemical staining was used to detect the expression of CD68 in 58 cases of gastric adenocarcinoma. The correlation between the distribution of CD68 + macrophages and clinicopathological features and prognosis was analyzed. Results: The number of infiltrating CD68 + macrophages in gastric cancer was correlated with pathological grade (P = 0.006), lymph node metastasis (P = 0.002) and TNM stage (P = 0.040), but not with sex, age, tumor location and tumor diameter Multivariate analysis showed that the maximum tumor diameter (P = 0.024, HR 3.347,95% CI 1.497-9.918), TNM stage (P = 0.019, HR 2.891, 95% CI 1.177-7.969) and CD68 expression P = 0.034, HR 2.598, 95% CI 0.887-7.912) were independent prognostic factors of gastric cancer. The survival curves suggested that patients with low infiltration of CD68 + macrophages had better prognosis (P = 0.011). Conclusion: The infiltration and distribution of CD68 + macrophages in gastric cancer have important clinical significance. The expression of CD68 is negatively correlated with the prognosis of gastric cancer patients.