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目的:通过动物实验判断芎附汤的急性毒性,为临床用药提供安全依据。方法:给予小鼠灌胃芎附汤,通过预实验测定半数致死量(LD50),并据此测定最大耐受量(MTD)。结果:急性毒性实验未能测出LD50,改测最大耐受量为240g/kg,相当于临床人用量的243倍。结论:芎附汤是安全有效的药物,可以在临床使用。
OBJECTIVE: To determine the acute toxicity of Xiong Fu Tang through animal experiments to provide a safety basis for clinical drug use. Methods: The mice were given gavage of Xiongfu Decoction and the LD50 was determined by preliminary experiment, and the maximum tolerated dose (MTD) was determined accordingly. Results: LD50 was not detected in acute toxicity test. The maximum tolerated dose was 240 g / kg, which was equivalent to 243 times of clinical dosage. Conclusion: Xiong Fu Tang is a safe and effective drug that can be used clinically.