论文部分内容阅读
干扰素(IFN)是丙型肝炎肝硬化治疗中唯一有效的药物。以前的研究采用生化指标应答来评估IFN的疗效,但在整个IFN治疗期间,生化指标并不能反应持续应答。为此本文作者采用检测HCV RNA水平以评估IFN疗效,为制定合理有效的IFN治疗方案提供依据。 研究对象为157例丙型肝炎肝硬化患者,系1993年2月～1994年10月期间收治的病例。诊断标准符合下列条件:①按Desmet标准肝纤维化达F4级;②RT-PCR法测定HCV RNA阳性;③血小板计数超过
Interferon (IFN) is the only effective treatment for hepatitis C cirrhosis. Previous studies used biochemical response to assess the efficacy of IFN, but biochemical markers did not respond to sustained response throughout IFN treatment. To this end the authors used to detect HCV RNA levels to assess the efficacy of IFN, in order to develop a reasonable and effective IFN treatment programs provide the basis. The object of study was 157 patients with hepatitis C cirrhosis, which were treated from February 1993 to October 1994. Diagnostic criteria meet the following conditions: ① according to Desmet liver fibrosis grade F4; ② RT-PCR method for the determination of HCV RNA positive; ③ platelet count exceeds