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本文探讨新生儿缺氧缺血性脑病(HIE)血清半胱氨酸酶-1(caspase-1)的变化,旨在为早期辅助诊断HIE及协助HIE临床分度提供依据。采用酶联免疫吸附法(ELISA)和免疫电泳法分别检测HIE患儿及正常足月儿出生后第3d血清caspase-1和CK-BB的水平。结果显示,血清caspase-1水平与HIE临床分度基本一致,可作为早期辅助诊断HIE的指标,对协助HIE临床分度具有重要价值。
This article discusses the changes of serum caspase-1 in neonatal hypoxic-ischemic encephalopathy (HIE) and aims to provide basis for early diagnosis of HIE and clinical HIE. The levels of caspase-1 and CK-BB on the 3rd day after birth in HIE infants and normal term infants were detected by enzyme-linked immunosorbent assay (ELISA) and immunoelectrophoresis respectively. The results showed that the level of serum caspase-1 and HIE clinical index is basically the same, can be used as an early diagnosis of HIE indicators, to help HIE clinical indexing has important value.