论文部分内容阅读
全世界每年有超过890万人被发现患有前列腺癌,其中26万人死亡。中国近年来发病率及死亡率逐年上升,位于泌尿系统肿瘤第三位~([1])。临床标本的组织病理分析和动物研究表明,传染性病原体、饮食致癌物、种族、年龄及其他因素引起前列腺上皮细胞损伤并诱发前列腺的炎症反应,病理生理学证据表明这些炎症反应可能导致突变~([2])。这些突变联合炎症介质和细胞增殖能力的增强是导致前列腺癌发生和发展的启动因素,其所导致的癌前病变形成包括增生性炎症萎缩、
More than 8.9 million people worldwide are found to have prostate cancer each year, 260,000 of whom die. In recent years, the morbidity and mortality of China have risen year by year, ranking the third in urinary system tumors ~ ([1]). Histopathological analysis and animal studies of clinical specimens show that infectious pathogens, dietary carcinogens, race, age and other factors cause prostatic epithelial cell damage and induce prostatic inflammatory responses, and that the pathophysiological evidence suggests that these inflammatory responses may result in mutations ([ 2]). The combination of these mutations in combination with inflammatory mediators and cell proliferation is a causative factor leading to the occurrence and development of prostate cancer, which leads to the formation of precancerous lesions including proliferative inflammatory atrophy,