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氟哌啶醇(HAL)是治疗精神分裂症的有效药物。氟哌啶醇的一种代谢产物即降解的氟哌啶醇[4-(4-氯苯)-α-(4-氟苯)-4-羟基-1-哌啶丁醇,RHAL]以相同或高于氟哌啶醇的浓度存在于病人血清中,也具有某些抗精神病活性。因此,同时测定氟哌啶醇和降解的氟哌啶醇浓度是有临床意义的。材料:氟哌啶醇、降解的氟哌啶醇、氯氟哌啶醇、磷酸氢二钾、丙醇-1、乙腈、甲醇、去离子水等。标准制备:制备浓度范围为0.1～10ng/ml的氟哌啶醇与降解的氟哌啶醇血浆标
Haloperidol (HAL) is an effective drug for the treatment of schizophrenia. Degradation of Haloperidol [4- (4-chlorophenyl) -α- (4-fluorophenyl) -4-hydroxy-1-piperidinebutanol, RHAL], a metabolite of haloperidol, Or higher than haloperidol present in the patient’s serum, also has some antipsychotic activity. Therefore, simultaneous determination of haloperidol and degradation of haloperidol concentration is of clinical significance. Materials: haloperidol, degraded haloperidol, haloperidol, dipotassium hydrogen phosphate, propanol-1, acetonitrile, methanol, deionized water and the like. Standard Preparation: Preparation of haloperidol in concentrations ranging from 0.1 to 10 ng / ml and degraded haloperidol plasma