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大量材料支持胸腺是免疫系统发育中的一个内分泌器官,而且可作为控制代谢和生殖的内分泌网络部分.先天性无胸腺裸鼠缺乏生殖功能,同时伴有垂体促性腺激素及下丘脑LRF浓度的降低.为进一步证明是否LRF、FSH、LH的改变是由于减少了胸腺激素的分泌所致,本文作者对其所作实验的结果进行了报道.作者采用的基本实验方法是:将122只无胸腺裸鼠(nu/nu)及190只正常杂合子鼠(nu/+),从生后1日起至21日,每日给予皮下注射,分别为:粗制胸腺提取液,半合成的胸腺激素第5部
A large number of materials support the thymus is an endocrine system in the development of the immune system, and can be used as part of the control of endocrine network of metabolism and reproduction. Congenital athymic nude mice lack of reproductive function, accompanied by pituitary gonadotropin and hypothalamic LRF concentration decreased To further confirm whether changes in LRF, FSH, and LH were due to diminished thymus hormone secretion, the authors reported the results of their experiments.1 The basic experimental approach used by the authors was to determine whether 122 athymic nude mice (nu / nu) and 190 normal heterozygous (nu / +) mice. Subcutaneous injections were given daily from day 1 to day 21 of postnatal day. They were crude thymus extract, semi-synthetic thymosin 5 unit