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采用体外大鼠肝微粒体系统和体内经饮水加氟（５０ｍｇ／Ｌ）同时或单独加硒（０．５ｍｇ／Ｌ）的方法，观察氟致大鼠体内、体外脂质过氧化作用及硒的拮抗作用。体外实验结果表明，加氟可使微粒体系统脂质过氧化物（ＬＰＯ）含量显著增加；同时加硒可结抗氟致微粒体系统的脂质过氧化作用。体内实验结果表明，饮水加氟（５０ｍｇ／Ｌ）可使大鼠血清ＬＰＯ含量显著增加，全血谷胱甘肽过氧化物酶（ＧＳＨ－Ｐｘ）活性和血清游离维生素Ｅ含量显著降低；饮水同时加硒（０．５ｍｇ／Ｌ）则可拮抗上述氟的效应。
In vitro rat liver microsomal system and the body by drinking water plus fluoride (50mg / L) at the same time or selenium alone (0.5mg / L) method to observe fluoride-induced in vivo and in vitro lipid peroxidation and selenium Antagonism. The results of in vitro experiments showed that adding fluoride can significantly increase the content of lipid peroxide (LPO) in the microsomal system; at the same time, selenium can endure the lipid peroxidation of fluoride-induced microsomal system. In vivo experiments showed that drinking water fluoride (50mg / L) can significantly increase serum LPO content, whole blood glutathione peroxidase (GSH-Px) activity and serum free vitamin E content was significantly reduced; drinking water at the same time Selenium (0.5mg / L) can antagonize the above effects of fluorine.