Plants maintaina dynamic balance between growth and defense,and optimize allocation of resources for sur-vival under constant pathogen infections.However,the underlying molecular regulatory mechanisms,espe-cially in response to biotrophic bacterial infection,remain elusive.Here,we demonstrate that DELLA proteins and EDS1,an essential resistance regulator,form a central module modulating plant growth-defense trade-offs via direct interaction.When infected by Pst DC3000,EDS1 rapidly promotes salicylic acid(SA)biosyn-thesis and resistion-related　gene expression to prime defense response,while pathogen infection stabilizes DELLA proteins RGA and RGL3 to restrict growth in a partially EDS1-dependent manner,which facilitates plants to develop resistance to pathogens.However,the increasingly accumulated DELLAs interact with EDS1 to suppress SA overproduction and excessive resistance response.Taken together,our findings reveal a DELLA-EDS1-mediated feedback regulatory loop by which plants maintain the subtle balance between growth and defense to avoid excessive growth or defense in response to constant biotrophic pathogen attack.