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艾滋病流行形势日益严峻已成为严重的公共卫生问题,安全有效的疫苗是防治艾滋病最为有效的手段。2009年底,美国和泰国研究人员共同宣布基于有过失败“前科”的两种疫苗(ALVAC和AIDSVAX)的联合使用可以将人体感染艾滋病病毒的风险降低31.2%,这是人类首次获得具有一定免疫保护效果的艾滋病疫苗。本文就两种疫苗单独和联合免疫的临床试验进行综述。
The increasingly serious AIDS epidemic has become a serious public health problem. A safe and effective vaccine is the most effective way to combat AIDS. At the end of 2009, researchers from the United States and Thailand jointly announced that the combined use of the two vaccines (ALVAC and AIDSVAX) that had failed “first aid” could reduce the human risk of HIV by 31.2%, the first time humans have acquired certain Immune protection effect of AIDS vaccine. This article reviews the clinical trials of both vaccines alone and in combination.