早在1909年Oppenheim首先注意到在脑内有淀粉样物的沉积。后来又发现该物多沉积于大脑皮层和软脑膜的中小动脉壁上,并与老年斑(SP)有密切关系。1927年Divry发现脑动脉壁和SP内的淀粉样物经刚果红染色后在旋光镜下呈现为一种绿色双折射物质,故早年文献采用嗜刚红性血管病、类斑块样血管病等名称来描述本病的各种不同的组织学表现,而近年则多采用大脑淀粉样血管病(Cerebral amyloid angiopathyCAA)这一名称。并经大量的病理资料证实,CAA多伴发于Alzheimer病(AD)和老年性痴 As early as 1909 Oppenheim first noted the deposition of amyloid in the brain. Later found that the more material deposited in the cerebral cortex and the pia mater artery wall, and with age spots (SP) are closely related. In 1927, Divry found that amyloid in the arterial wall and SP in SP was stained with Congo red and appeared as a green birefringent substance under polarimetry. Therefore, in the early years, the literature used the study of neovascular vascular disease and plaque-like vascular disease Name to describe the different histological manifestations of the disease, while in recent years the name cerebral cerebral amyloid angiopathy (CAA) is frequently used. And confirmed by a large number of pathological data, CAA often accompanied by Alzheimer’s disease (AD) and senile