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目的探讨肝癌患者经射频联合脐血CIK细胞治疗前后免疫水平的变化、机制。方法采用流式细胞术对比30例肝癌患者经射频联合脐血CIK细胞治疗前与治疗后1周时T细胞、B细胞、NK细胞、Th细胞、Ts细胞及Th细胞/Ts细胞的变化。结果 30例肝癌患者经射频联合脐血CIK细胞治疗前后T淋巴细胞、NK细胞、Th细胞、Ts细胞及Th细胞/Ts细胞比较,差异具有统计学意义(P<0.05);B淋巴细胞比较,差异无统计学意义(P>0.05)。结论射频联合脐血CIK细胞治疗可明显提高肝癌患者T淋巴细胞介导的细胞免疫水平。
Objective To investigate the changes and mechanisms of immune status of patients with hepatocellular carcinoma before and after treatment with radiofrequency combined with cord blood CIK cells. Methods Flow cytometry was used to compare the changes of T cells, B cells, NK cells, Th cells, Ts cells and Th cells / Ts cells in 30 cases of HCC patients before radiotherapy combined with cord blood CIK cells and 1 week after treatment. Results T lymphocytes, NK cells, Th cells, Ts cells and Th cells / Ts cells before and after radiofrequency combined with umbilical cord blood CIK cells were significantly different in 30 HCC patients (P <0.05). Compared with B lymphocytes, The difference was not statistically significant (P> 0.05). Conclusion RFC combined with umbilical cord blood CIK cell therapy can significantly improve the level of T lymphocyte-mediated cellular immunity in patients with hepatocellular carcinoma.