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目的部分抗－ＨＢｓ阳性者仍有活动性肝病存在，其病因还不十分清楚．本研究旨在探讨血清抗ＨＢｓ阳性慢性肝病患者的病因．方法应用套式聚合酶链反应检测血清抗ＨＢｓ阳性慢性肝病患者血清中ＨＢＶＤＮＡ和ＨＣＶＲＮＡ．患者３２例，男２５例，女７例，平均年龄４１７岁（２１岁～６３岁），其中慢性肝炎１８例，肝硬变１４例．９例慢性肝炎和５例肝硬变经肝活检证实，其余为临床诊断．结果血清中ＨＢＶＤＮＡ和ＨＣＶＲＮＡ的检出率分别为６２５％（２０／３２）和２８１％（９／３２）；ＨＢＶＤＮＡ和（或）ＨＣＶＲＮＡ总检出率为８１３％（２６／３２）．结论血清抗ＨＢｓ阳性慢性肝病患者的病因多数与ＨＢＶ和（或）ＨＣＶ感染有关．
The purpose of some anti-HBs positive still active liver disease exists, the etiology is not yet clear. This study aimed to explore the etiology of serum anti-HBs positive chronic liver disease. Methods Serum HBVDNA and HCV RNA were detected by nested polymerase chain reaction in patients with anti-HBs positive chronic liver disease. 32 patients, 25 males and 7 females, the average age of 41.7 years (21 years to 63 years), of which 18 cases of chronic hepatitis, liver cirrhosis in 14 cases. 9 cases of chronic hepatitis and 5 cases of cirrhosis confirmed by liver biopsy, the rest for the clinical diagnosis. Results The detection rates of HBVDNA and HCV RNA in serum were 625% (20/32) and 281% (9/32), respectively. The total detection rate of HBVDNA and HCVRNA was 813% (26 / 32). Conclusions Most of the etiological agents in patients with anti-HBs positive chronic liver disease are related to HBV and / or HCV infection.