内毒素(Endotoxin, ET)系指革兰氏阴性细菌细胞壁中的类脂多糖体(Lipopolysaccharide,LPS)成分。在结构上由三大部分组成,即“O”特异性侧链(“O”抗原),核心(Core)多糖及类脂体A(Lipid A)。类脂体A为内毒素的主要毒性成分及生物学活性中心。近数十年来,随着先进研究手段的采用,在内毒素研究领域内取得了许多成果。目前,已基本弄清了 Endotoxin (ET) refers to the components of the lipopolysaccharide (LPS) in the cell wall of Gram-negative bacteria. It is structurally composed of three major components: the “O” specific side chain (“O” antigen), the core polysaccharide and Lipid A. Lipid A is the major toxic component of endotoxin and biological activity center. In recent decades, with the adoption of advanced research methods, many achievements have been made in the field of endotoxin research. At present, it has basically been clarified