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目的探讨多种肿瘤标志物联合检测对原发性肝癌的诊断价值。方法用化学发光法检测50例原发性肝癌(PHC)患者、40例肝硬化患者及100例健康体检者血清肿瘤标志物AFP、CA199、β2-MG的水平。结果原发性肝癌各项指标与正常相比较三项标志物差异均有统计学意义(P<0.01)。原发性肝癌组单项AFP、CA199、β2-MG阳性率分别为68%、58%、76%,3项联合检测阳性率为84%。结论AFP、CA199、β2-MG三项肿瘤标志物联合检测可提高肝癌的阳性符合率,对诊断及鉴别诊断肝癌具有重要意义。
Objective To investigate the diagnostic value of multiple tumor markers combined detection of primary liver cancer. Methods The levels of serum tumor markers AFP, CA199 and β2-MG in 50 patients with primary liver cancer (PHC), 40 patients with cirrhosis and 100 healthy controls were detected by chemiluminescence method. Results There were significant differences in the three markers between the indexes of primary hepatocellular carcinoma and normal (P <0.01). The positive rates of single AFP, CA199 and β2-MG in primary hepatocellular carcinoma were 68%, 58% and 76% respectively, and the positive rates of the three combined tests were 84%. Conclusion The combined detection of AFP, CA199 and β2-MG tumor markers can improve the coincidence rate of hepatocellular carcinoma, which is of great significance in the diagnosis and differential diagnosis of hepatocellular carcinoma.