Yamamoto等用许多种诱变剂其中包括纺锤体毒物长春新硷,研究了诱发微核的时间效应。与其它诱变剂不同,长春新硷仅在一次给药后6小时,微核率明显增高。这种结果比Cole等描述的小鼠骨髓红细胞生成的预定时间早几小时。本文研究了一些诱变剂的早期效应,以试图阐明Cole模型和上述结果之间的明显的不一致。材料和方法实验所用的动物,全部为NMRI系雄性小鼠,体 Yamamoto et al. Used a variety of mutagens, including the spindle poison vincristine, to study the time effect of induced micronuclei. Unlike other mutagens, vincristine significantly increased micronucleus rate 6 hours after one dose. This result is a few hours earlier than the predicted time of mouse bone marrow erythropoiesis as described by Cole et al. This article examines the early effects of some mutagens in an attempt to elucidate the apparent inconsistency between the Cole model and the above results. Materials and Methods Animals used in the experiment were all male NMRI mice