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目的:通过消风Ⅱ号胶囊对去肾上腺与非去肾上腺大鼠佐剂性关节炎(AA)的作用,探讨消风Ⅱ号胶囊治疗大鼠佐剂性关节炎的作用机制。方法:应用弗氏完全佐剂诱导去肾上腺与非去肾上腺大鼠实验性关节炎模型,于第7d开始灌胃给予消风Ⅱ号胶囊,连续21d。测量大鼠足肿胀度,HE染色观察大鼠踝关节病理组织学变化。结果:消风Ⅱ号胶囊对去肾上腺AA大鼠佐剂注射侧肿胀度抑制率为9.6%,对另侧后肢因迟发型超敏反应引起的足肿胀抑制率30.8%,可减轻大鼠的耳部红斑、前肢和尾部病变的损害。病理组织学显示大鼠关节水肿减轻,淋巴细胞浸润明显减少,滑膜增生受到一定抑制,但其作用低于非去肾上腺AA大鼠。结论:消风Ⅱ号胶囊不仅有一定的皮质激素样作用,同时也可通过调节肾上腺皮质功能而发挥治疗作用。
Objective: To investigate the effect of Xiaofeng Ⅱ capsule on adjuvant arthritis (AA) in adrenal and non-adrenal rats and to explore the mechanism of Xiaofeng Ⅱ capsule in adjuvant arthritis in rats. Methods: The model of experimental arthritis in adrenal and non-adrenal rats was induced by complete Freund’s adjuvant, and Xiaofeng Ⅱ capsule was administered intragastrically on the 7th day for 21 consecutive days. The degree of paw swelling in rats was measured and the histopathological changes of the ankle joint were observed by HE staining. Results: Xiaofeng Ⅱ capsule on adjuvant injection side of rats with adrenal AA swelling degree of inhibition was 9.6%, on the other side of the hind legs due to delayed type hypersensitivity induced foot swelling 30.8% inhibition, can reduce the rat ear Erythema, forelimb and caudal lesion lesions. Histopathology showed that joint edema was alleviated, lymphocyte infiltration significantly reduced, synovial hyperplasia was inhibited, but its effect was lower than non-adrenal AA rats. Conclusion: Xiaofeng Ⅱ capsule not only has certain corticosteroid-like effect, but also can play a therapeutic role by regulating adrenocortical function.