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目的：探讨苯妥英钠的致突变作用。方法：用小鼠骨髓细胞微核试验和小鼠睾丸染色全畸变试验。结果：高浓度苯妥英钠能引起小鼠PCE微核的发生率升高；在睾丸染色体畸变试验中，表现为诱导的小鼠精母细胞染色体畸变率升高。结论：苯妥英钠可能具有致突变作用。
Objective: To investigate the mutagenic effect of phenytoin sodium. Methods: The mouse bone marrow micronucleus test and mouse testis staining were used in the experiment. Results: Phenytoin with high concentration could cause the increased incidence of micronuclei in PCE mice. In the testicular chromosome aberration test, the chromosome aberration rate induced by phenytoin in mice increased. Conclusion: Phenytoin sodium may have mutagenic effects.