目的阐明脊柱结核抗结核药物副作用发生情况及预防、处理措施。方法对1998年1月至2007年12月间经我院确诊治疗的脊柱结核患者156例进行临床回顾性研究。结果发生抗结核药物副作用68例(43.6%)114例次,以肝功能损害、位听神经损害、胃肠反应及视力损害为主(86.0%),因副作用致终止治疗4例,占2.6%。其中发生1种同类别副作用43例,2种副作用20例,3种以上副作用5例。抗结核药物的副作用多出现于用药早期,2个月内占67.5%。结论抗结核药物引起的副作用较常见,临床常易忽视,若发生抗结核药物严重副作用,易引起严重后果,应引起临床医生高度重视。 Objective To clarify the occurrence and prevention and treatment of side effects of antituberculosis drugs of spinal tuberculosis. Methods From January 1998 to December 2007, 156 cases of spinal tuberculosis confirmed by our hospital were retrospectively studied. Results A total of 68 patients (43.6%) had 114 side-effects of antituberculosis drugs. Among them, liver dysfunction, auditory nerve damage, gastrointestinal reaction and visual impairment were the major causes (86.0%). Four patients were terminated by side effects (2.6%). There were 43 cases of one kind of side effects in same class, 20 cases of 2 kinds of side effects and 5 cases of 3 kinds of side effects. Side effects of anti-TB drugs appear in the early medication, 67.5% within 2 months. Conclusion The side effects caused by antituberculosis drugs are more common and clinically often overlooked. If serious side effects of antituberculosis drugs occur, they may cause serious consequences and should be paid great attention to by clinicians.