恶性肿瘤骨转移是肿瘤晚期常见的并发症之一,最易发生骨转移的肿瘤包括乳腺、肺、前列腺,疼痛、病理性骨折、脊髓压迫、高钙血症是骨转移的主要临床并发症,最常见并影响生活质量的是顽固性骨痛,临床上的止痛措施多种多样,但多为单纯镇痛治疗,不能控制骨溶解,减轻骨质破坏,骨痛 Bone metastasis of malignant tumor is one of the most common complications in late stage of tumor. The most prone to bone metastases include breast, lung, prostate, pain, pathological fracture, spinal cord compression and hypercalcemia, which are the main clinical complications of bone metastasis. The most common and affect the quality of life is refractory bone pain, clinical painkilling measures varied, but mostly simple analgesic treatment, can not control osteolysis, reduce bone destruction, bone pain