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目的:研究慢性心力衰竭(CHF)患者血红蛋白水平变化与血清肿瘤坏死因子-α(TNF-α)及其心功能的关系。方法:对入选的121例CHF患者测定了血红蛋白和血清TNF-α水平,超声心动图测量左室射血分数(LVEF),评价心功能;按血红蛋白水平分为CHF贫血组和非贫血组,同时选择27例正常人作为对照组。结果:贫血组CHF患者血清TNF-α含量均升高,明显高于非贫血组CHF患者和健康对照组(P<0.01);随着贫血程度的加重,CHF患者血清TNF-α含量进一步升高(P<0.01)。结论:CHF患者Hb水平的降低和TNF-α水平的升高参与了心功能不全发生发展的病理生理过程,而CHF患者贫血的出现使心功能不全程度更加恶化。
Objective: To investigate the relationship between hemoglobin level and serum tumor necrosis factor-α (TNF-α) and its cardiac function in patients with chronic heart failure (CHF). Methods: The levels of hemoglobin and serum TNF-α were measured in 121 CHF patients. The left ventricular ejection fraction (LVEF) was measured by echocardiography, and the cardiac function was evaluated. According to hemoglobin level, patients were divided into CHF anemia group and non-anemia group 27 normal subjects were chosen as the control group. Results: The serum levels of TNF-α in patients with anemia were significantly higher than those in non-anemia patients and healthy controls (P <0.01). The levels of TNF-α in patients with CHF were further increased as the degree of anemia increased (P <0.01). CONCLUSIONS: Hb levels and TNF-α levels in CHF patients are involved in the pathophysiological process of cardiac dysfunction. However, the occurrence of anemia in CHF patients worsens the degree of cardiac insufficiency.