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急性胰腺炎(acute pancreatitis,AP)是常见的急腹症之一。近年大量的研究证实,AP局部、全身炎症反应与肿瘤坏因子-α(TNF-α)、白细胞介素-1β(IL-1β)等多种细胞因子有关,而核因子-κB(nu- clear factor—kappa B,NF-κB)在其基因表达上起着关键作用。NF-κB是一种具有基因转录调节作用的核蛋白,调控多种细胞因子的表达。因此,研究如何抑制NF-κB的活化,减少促炎基因的表达,从而减轻组织损伤和炎症反应,在AP治疗上有着重要意义。
Acute pancreatitis (AP) is one of the common acute abdomen diseases. In recent years, a large number of studies have shown that AP local inflammation and systemic inflammatory response and tumor necrosis factor-α (TNF-α), interleukin -1β (IL-1β) and other cytokines, and nuclear factor-κB factor-kappa B, NF-κB) plays a key role in its gene expression. NF-κB is a nuclear protein with gene transcription regulation, which regulates the expression of various cytokines. Therefore, to study how to inhibit the activation of NF-κB, decrease the expression of proinflammatory genes and reduce the tissue damage and inflammatory reaction is of great significance in the treatment of AP.