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目的:探讨认知功能正常时HIV感染者与正常人的静息态脑功能连接情况。方法:按照入选标准搜集25例HIV感染者和27例健康志愿者作为正常对照组,比较蒙特利尔认知评估量表评分、年龄、性别、教育水平的差异。应用静息态脑功能技术以双侧大脑各区为种子点,分析两组各种子点与全脑功能连接的差异,体素P取0.005,团簇P取0.05。结果:HIV感染组与正常对照组各种子点均有统计学差异,经多重校正后有19个种子点8个脑区差异具有统计学意义。HIV感染组在以左侧额极内侧、双侧海马、双侧前扣带回、左侧顶叶、左侧丘脑、左侧梭状回的种子点与全脑的功能连接高于正常组;HIV感染组在以双侧视觉皮层枕叶、左侧岛叶区域的种子点与全脑的功能连接低于正常组;HIV感染组在以右侧运动皮层、左侧顶下叶的种子点与全脑的功能连接与正常组比较既有升高又有降低。结论:HIV感染者认知功能正常时的静息态脑功能连接与正常人有显著差异,提示HIV感染者在认知功能正常时脑功能连接可能已经出现异常,HIV病毒可能影响脑功能的连接。
Objective: To investigate the relationship between resting state brain function of HIV-infected persons and normal subjects with normal cognitive function. Methods: Twenty-five HIV-infected patients and 27 healthy volunteers were recruited as the normal control group according to the inclusion criteria. The differences in cognitive assessment score, age, sex and educational level in Montreal were compared. Application of resting state brain function to the brain regions of the two sides as a seed point, the two groups of sub-points and whole brain functional connectivity differences, voxel P 0.005, cluster P 0.05. Results: There were significant differences among the various sub-spots in HIV-infected group and normal control group. There were statistically significant differences in 8 sub-areas of 19 seeds after multiple calibration. In the HIV infection group, the functional connection with the whole brain in the upper extremity of the left frontal pole, bilateral hippocampus, bilateral anterior cingulate gyrus, left parietal lobe, left thalamus and left fusiform gyrus was higher than that in the normal group; HIV infection group in the bilateral visual cortex occipital lobe, the left island region of the seed point and the whole brain functional connection is lower than the normal group; HIV infection group in the right motor cortex, the left lower top of the seed point and Whole-brain functional connectivity has both increased and decreased compared with the normal group. Conclusion: There is a significant difference in resting state brain function connection between HIV infected persons with normal cognitive function and normal subjects, suggesting that HIV infection may have an abnormality in brain function when cognitive function is normal and HIV virus may affect the connection of brain function .