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目的探讨抑制素A(Inhibin A)、激活素A(Activin A)、人绒毛膜促性腺激素β(β-h CG)联合检测在异位妊娠的早期诊断中的价值,并分析其在异位妊娠保守治疗中的应用价值。方法选取2015年2月-2016年12月在该院接受保守治疗的早期未破裂异位妊娠患者60例作为观察对象(观察组),同时选取同期在该院接受产检的宫内妊娠孕妇60例作为对照(对照组)。观察两组患者血清Inhibin A、Activin A、β-h CG水平,比较不同临床特征和治疗前后异位妊娠患者血清Inhibin A、Activin A、β-h CG水平的差异。结果观察组患者的血清Inhibin A、Activin A、β-h CG水平低于对照组(t=34.882、22.380、158.419,P<0.001);不同年龄、是否合并子宫肌瘤和不同异位妊娠部位患者的血清Inhibin A、Activin A、β-h CG水平差异无统计学意义(P>0.05);Inhibin A、Activin A、β-h CG联合检测的灵敏度为60.25,特异度为68.84,明显高于单项检测;保守治疗后,异位妊娠患者的Inhibin A、Activin A、β-h CG水平均较治疗前降低(均P<0.001)。结论 Inhibin A、Activin A、β-h CG联合检测对异位妊娠有较好的诊断价值,且保守治疗后可明显下降。
Objective To investigate the value of combined detection of Inhibin A, Activin A and β-h CG in the early diagnosis of ectopic pregnancy, The value of conservative treatment of pregnancy. Methods Sixty patients with early unruptured ectopic pregnancy who underwent conservative treatment in our hospital from February 2015 to December 2016 were selected as the observation group (observation group), and 60 pregnant women undergoing intrauterine pregnancy As a control (control group). The levels of serum Inhibin A, Activin A and β-h CG in two groups of patients were observed. The differences of serum levels of Inhibin A, Activin A and β-h CG in patients with different clinical features and before and after ectopic pregnancy were compared. Results The levels of serum Inhibin A, Activin A and β-h CG in the observation group were lower than those in the control group (t = 34.882,22.380,158.419, P <0.001). At different ages, patients with uterine fibroids and different ectopic pregnancy (P> 0.05). The combined detection of Inhibin A, Activin A and β-h CG showed a sensitivity of 60.25 and a specificity of 68.84, which was significantly higher than that of single After conservative treatment, the levels of Inhibin A, Activin A and β-h CG in patients with ectopic pregnancy were lower than those before treatment (all P <0.001). Conclusion The combination of Inhibin A, Activin A and β-h CG has a good diagnostic value for ectopic pregnancy, and can be significantly decreased after conservative treatment.