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目的探讨奥曲肽治疗肝硬化上消化道出血的疗效及安全性。方法将肝硬化上消化道出血患者60例随机分为观察组和对照组各30例。对照组予以止血、补液、输血、防治休克等对症治疗,并持续静脉滴注垂体后叶素和硝酸甘油;观察组在对照组治疗基础上,将垂体后叶素改为奥曲肽0.1mg加至生理盐水20ml中,首次缓慢静脉注射,后以25μg/h静脉滴注。比较2组的临床疗效及不良反应。结果观察组总有效率高于对照组,不良反应发生率低于对照组,差异均有统计学意义(P<0.05)。结论奥曲肽治疗肝硬化上消化道出血疗效显著,不良反应少,值得临床推广应用。
Objective To investigate the efficacy and safety of octreotide in the treatment of upper gastrointestinal bleeding caused by cirrhosis of the liver. Methods Sixty patients with cirrhosis and upper gastrointestinal bleeding were randomly divided into observation group and control group, 30 cases each. The control group was given hemostasis, fluid replacement, blood transfusion, prevention and treatment of shock and other symptomatic treatment, and continuous intravenous infusion of vasopressin and nitroglycerin; observation group in the control group based on the treatment, the pituitrin into octreotide 0.1mg added to the physiology Saline 20ml, the first slow intravenous injection, after 25μg / h intravenous infusion. The clinical efficacy and adverse reactions of the two groups were compared. Results The total effective rate in the observation group was higher than that in the control group, and the incidence of adverse reactions was lower than that in the control group (P <0.05). Conclusion octreotide treatment of cirrhosis of upper gastrointestinal bleeding significant effect, fewer adverse reactions, it is worthy of clinical application.