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ＩＶ型胶原为肝细胞间质成分，其代谢与肝纤维化有关。我们测定各种肝病患者１４１例，以观察血清ＩＶ型胶原的变化，研究其临床价值，并选３０例健康献血员为正常对照组。结果显示：慢性肝炎、失代偿期肝硬化、肝硬化合并肝癌及肝癌患者血清ＩＶ－Ｃ均高于正常对照组，且失代偿期肝硬化，肝硬化合并肝癌与慢性肝炎相比亦显著升高（Ｐ＜０．０５）。结论：放免法测定血清ＩＶ－Ｃ有助于肝纤维化诊断，并对肝硬化诊断有一定价值。
Type IV collagen hepatocyte interstitial components, its metabolism and liver fibrosis. We measured 141 cases of various liver disease patients to observe the changes of serum type IV collagen, to study its clinical value, and select 30 healthy blood donors as the normal control group. The results showed that the serum levels of IV-C in patients with chronic hepatitis, decompensated cirrhosis, cirrhosis and hepatocellular carcinoma were significantly higher than those in the normal control group, and the decompensated cirrhosis, cirrhosis and hepatocellular carcinoma were also significantly higher than those in chronic hepatitis Increased (P <0.05). Conclusion: Radioimmunoassay for the determination of serum IV-C is helpful for the diagnosis of liver fibrosis and has some value for the diagnosis of cirrhosis.