鞘内注射氯甲谋吟（MTX）可致严重的神经毒性，也有造成死亡的报告。我们应用甲酸四氢叶酸钙抢救2例鞘注MIX后出现严重反应的病例，效果较好，报告如下。例1，男，26岁，因发热半月、皮肤散在出血点，胸骨压病（＋），肝助下未触及，脾助下1．0cm。骨田：原始粒细胞占0·78，CD Intrathecal injection of chlorpromazine (MTX) can cause severe neurotoxicity, there are also reports of death. We use calcium formate folate rescue 2 cases of severe reaction after sheath injection of MIX, the effect is better, the report is as follows. Example 1, male, 26 years old, due to fever half months, the skin scattered bleeding point, sternal pressure disease (+), liver help not touched, spleen help 1.0cm. Bone field: primitive granulocytes accounted for 0.78, CD