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目的 探讨亚低温对高血压病脑出血的疗效及对血清超氧化物歧化酶 (SOD)、过氧化脂质 (LPO)的影响。方法 57例高血压病脑出血患者随机分为亚低温组 (2 9例 )及常温对照组 (2 8例 ) ,亚低温组入院或术后 6h入NICU病房行亚低温治疗 ,治疗前及治疗后第 3、7天分别测定血清SOD、LPO含量变化 ,并与常温对照组进行比较。结果 治疗前两组患者SOD、LPO含量无显著差异 (P >0 .0 5) ;经治疗后两组患者SOD水平均上升 ,LPO水平均下降 ,治疗后第 3、7天 ,亚低温组血清SOD水平较常温对照组明显升高 ,LPO明显降低 ,两组比较差异显著 ((P <0 .0 1 )。亚低温组病死率 (1 3 8% )明显低于常温对照组 (32 1 % ) (P <0 .0 5)。结论 亚低温治疗可有效抑制氧自由基生成 ,减轻脂质过氧化反应 ,对脑组织的结构与功能起保护作用 ,明显改善高血压病脑出血患者的预后
Objective To investigate the effects of mild hypothermia on hypertensive cerebral hemorrhage and its effects on serum superoxide dismutase (SOD) and lipid peroxidation (LPO). Methods Fifty-seven patients with hypertensive intracerebral hemorrhage were randomly divided into mild hypothermia group (n = 29) and normal temperature control group (n = 28). Patients in mild hypothermia group were admitted to NICU ward at 6h after operation, On the 3rd and 7th day, the changes of serum SOD and LPO contents were measured respectively and compared with the normal temperature control group. Results There was no significant difference in SOD and LPO levels between the two groups before treatment (P> 0.05). After treatment, the SOD level and the LPO level of both groups were both decreased. On the 3rd and 7th day after treatment, The level of SOD in the mild hypothermia group (13.8%) was significantly lower than that in the normal temperature control group (32.1%), and the level of SOD in the mild hypothermia group was significantly higher than that in the normal temperature control group (P <0.01) ) (P <0.05) .Conclusion Mild hypothermia treatment can effectively inhibit the generation of oxygen free radicals, reduce lipid peroxidation, play a protective role on the structure and function of brain tissue, significantly improve the prognosis of patients with hypertensive intracerebral hemorrhage