【摘 要】
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Hypoxia-inducible factors (HIFs) are transcriptional regulators playing important roles in adapting various types of cells to physiological and pathological hypoxia cues. Three structurally related, oxygen-sensitive HIFα proteins have been identified (HIF
【机 构】
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Department of Neurology,School of Medicine,the University of California,Davis;Institute for Pediatri
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Hypoxia-inducible factors (HIFs) are transcriptional regulators playing important roles in adapting various types of cells to physiological and pathological hypoxia cues. Three structurally related, oxygen-sensitive HIFα proteins have been identified (HIF1α, HIF2α, and HIF3α), among which HIF3α has weak transcriptional capacity because of the absence of the C-terminal transactivation domain as present in HIF1α and HIF2α.
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