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目的 :观察新清宁配合小剂量持续胃肠透析治疗尿毒症的临床疗效。方法 :57例临床确诊的尿毒症患者随机分为 3组 :A组 18例 ,为小剂量持续胃肠透析组 ,口服胃肠透析液 ,每次 10 0 0ml,每天 2～3次 ;B组 2 0例 ,为中西医结合组 ,治疗在A组的基础上加用中药大黄制剂———新清宁 ,每次 5～ 10片 ,每天3次 ;C组 19例 ,为对照组 ,口服包醛氧化淀粉 ,每次 5～ 10 g ,每天 3次。观察患者治疗前后的临床表现、肾功能、营养代谢及电解质酸碱变化 ,疗程 11个月。结果 :与治疗前和对照组比较 ,A、B两组治疗后临床症状明显改善 ,生活质量提高 ,营养状况良好 ,血肌酐 (SCr)、尿素氮 (BUN)、血磷 (SP)、血尿酸 (UA)水平明显下降 ,二氧化碳结合力 (CO2 CP)、内生肌酐清除率 (CCr)、体重及同侧上臂肌围 (AMC)升高。B组除上述变化外 ,血清甘油三酯 (TG)水平亦有所下降 ,肾衰进展速度较A组进一步减慢。C组治疗后各项指标无好转 ,SCr较治疗前明显升高。结论 :中药大黄制剂配合小剂量持续胃肠透析治疗尿毒症疗效确切 ,为慢性肾衰尿毒症非替代疗法提供了一个新的治疗手段。
Objective: To observe the clinical efficacy of Xin Qingning combined with low-dose continuous gastrointestinal dialysis in the treatment of uremia. Methods: Fifty-seven patients with clinically diagnosed uremia were randomly divided into three groups: group A (18 cases), low-dose continuous gastrointestinal dialysis group, oral gastrointestinal dialysis fluid, each 100ml, 2 to 3 times a day; group B 20 cases for the Integrative Medicine Group, the treatment in the A group based on the use of traditional Chinese medicine rhubarb agent --- Xin Qingning, each 5 to 10 tablets 3 times a day; C group of 19 patients for the control group, oral Packed aldehyde oxidized starch, each 5 ~ 10 g, 3 times a day. Observed before and after treatment of patients with clinical manifestations, renal function, nutritional metabolism and electrolyte acid-base changes, treatment for 11 months. Results: Compared with those before treatment and control group, the clinical symptoms in group A and group B improved obviously, the quality of life improved, the nutritional status was good, serum creatinine (SCr), blood urea nitrogen (BUN), serum phosphorus (SP) (UA), carbon dioxide (CO2 CP), endogenous creatinine clearance (CCr), body weight and ipsilateral upper arm muscle (AMC) increased. In addition to the above changes in group B, serum triglyceride (TG) levels also declined, renal failure progress more slowly than the A group. C group after treatment, no improvement of the indicators, SCr was significantly higher than before treatment. Conclusion: The Chinese medicine rhubarb combined with low-dose continuous gastrointestinal dialysis treatment of uremia curative effect is exact, provides a new treatment for chronic renal failure uremia non-replacement therapy.