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转化生长因子β是肿瘤细胞、微环境基质细胞和免疫调节细胞分泌的功能最强的免疫抑制因子,对T细胞、NK细胞、DC细胞均有显著抑制作用。TGF-β信号通路可分为Smad依赖途径和Smad非依赖途径,许多恶性肿瘤存在TGF-β信号通路的异常改变。反义RNA或RNA干扰策略、大分子单克隆抗体、小分子激酶抑制剂和缺陷型TGF-β受体等研究为肿瘤的靶向治疗提供了新的方法和机遇。
Transforming growth factor β is the most potent immunosuppressive factor secreted by tumor cells, microenvironmental stromal cells and immunoregulatory cells, and has a significant inhibitory effect on T cells, NK cells and DC cells. TGF-β signaling pathway can be divided into Smad-dependent and Smad-independent pathways, many malignant tumors there TGF-β signaling abnormalities. Antisense RNA or RNA interference strategies, macromolecular MAbs, small molecule kinase inhibitors and defective TGF-β receptors provide new approaches and opportunities for targeted therapies.