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目的分析哈萨克族健康体检人群尿酸与糖、脂代谢关系。方法收集2012年1月-12月哈萨克族健康体检人员的血液,检测其生化指标并进行统计分析。结果哈萨克族健康体检人群中高尿酸血症的检出率为10.5%,高胆固醇血症的检出率为13.9%、高甘油三酯血症的检出率为39.5%、高血糖的检出率为11.9%。哈萨克族男性和女性甘油三酯、尿酸、总胆固醇和空腹血糖水平以及高尿酸血症、高甘油三酯血症、高胆固醇血症、高血糖的检出率均表现出性别差别(P<0.05)。与其他民族不同哈萨克族女性甘油三酯水平和高甘油三酯血症的检出率差别均高于男性(P<0.05)。高尿酸组和正常人群组相比较,尿酸、糖脂代谢指标水平以及高尿酸血症、高脂血症、高血糖等代谢性疾病的检出率也均高于对照人群。结论受检人群尿酸和糖、脂代谢表现出性别差别和民族特点,而且受到尿酸代谢的影响,糖脂代谢指标也向对机体不利的方向发生变化,糖、脂代谢紊乱的发生率也增加。因此通过改变生活方式和膳食习惯及早控制尿酸水平和高尿酸血症的发病率,对于减少哈萨克族人群糖、脂代谢紊乱以及由其引发的心脑血管疾病和糖尿病的发生具有重要的意义。
Objective To analyze the relationship between uric acid and glucose and lipid metabolism in Kazakh healthy physical examination population. Methods Blood samples were collected from January to December 2012 in Kazakh health checkups, and their biochemical parameters were tested and statistically analyzed. Results The detection rate of hyperuricemia in Kazakh health examination population was 10.5%, the detection rate of hypercholesterolemia was 13.9%, the detection rate of hypertriglyceridemia was 39.5%, the detection rate of hyperglycemia 11.9%. The prevalence of triglyceride, uric acid, total cholesterol and fasting blood glucose, as well as the prevalence of hyperuricemia, hypertriglyceridemia, hypercholesterolemia and hyperglycemia in Kazakh and Kazak women showed gender differences (P <0.05 ). The differences of detection rates of triglyceride level and hypertriglyceridemia between Kazak women and other ethnic groups were higher than those of male (P <0.05). Hyperuricemia group and the normal population group, uric acid, glucose and lipid metabolism index levels and hyperuricemia, hyperlipidemia, hyperglycemia and other metabolic disease detection rates were also higher than the control population. Conclusion The uric acid, glucose and lipid metabolism in the subjects showed gender differences and ethnic characteristics, but also influenced by uric acid metabolism. The indicators of glucose and lipid metabolism also changed in the unfavorable direction to the body, and the incidence of glucose and lipid metabolic disorders also increased. Therefore, by changing the lifestyle and dietary habits and early control of uric acid levels and the incidence of hyperuricemia, to reduce the Kazakh population sugar, lipid metabolism disorders and the cardiovascular and cerebrovascular diseases and diabetes caused by its occurrence is of great significance.