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目的:观察大黄联合抗生素治疗脑出血后肺部感染的临床疗效。方法:96例急性高血压脑出血血肿清除术后并发肺部感染患者随机分为治疗组(56例)和对照组(40例)。对照组应用抗生素治疗,治疗组在抗生素治疗的基础上加用大黄6 g,以温开水100 mL调匀后经胃管鼻饲,每日2次,共治疗7天。治疗结束后比较和评价两组的治疗效果效果。结果:治疗组患者肺啰音消失的时间、炎症消散的时间和平均治愈天数分别为3.52±1.81、10.32±3.25、10.73±3.26天,较对照组(分别为10.86±3.43、13.51±2.66、14.73±3.11)均显著缩短,差异有显著统计学意义(P<0.01)。治疗组和对照组治疗总有效率分别为94.64%和85%,差异有统计学意义(P<0.05)。两组不良反应的发生率比较无统计学差异(P>0.05)。结论:大黄联合抗生素治疗脑出血术后合并肺部感染,可缩短治疗时间,提高疗效,且无严重不良反应。
Objective: To observe the clinical effect of Rhubarb combined with antibiotics in the treatment of pulmonary infection after intracerebral hemorrhage. Methods: A total of 96 patients with acute hypertensive intracerebral hemorrhage complicated with pulmonary infection after hematoma removal were randomly divided into treatment group (56 cases) and control group (40 cases). The control group was treated with antibiotics. The treatment group was treated with rhubarb 6 g on the basis of antibiotic treatment. After being evenly heated with 100 mL of warm water, the patients were treated by nasogastric feeding twice daily for 7 days. After treatment, the effects of treatment were compared and evaluated. Results: The disappearance of pulmonary rales, the disappearance of inflammation and the average number of days of cure were 3.52 ± 1.81,10.32 ± 3.25,10.73 ± 3.26 days in the treatment group compared with the control group (10.86 ± 3.43,13.51 ± 2.66,14.73 ± 3.11) were significantly shortened, the difference was statistically significant (P <0.01). The total effective rate of treatment group and control group were 94.64% and 85% respectively, with significant difference (P <0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusion: Rhubarb combined with antibiotics in the treatment of intracerebral hemorrhage complicated with pulmonary infection can shorten the treatment time and improve efficacy, and no serious adverse reactions.