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目的分析宁波市鄞州区49 818例高血压患者同型半胱氨酸(Hcy)水平及高Hcy血症患病情况,为制定有效的防控策略提供依据。方法选取2014年1月-12月宁波市鄞州区体检的高血压患者为研究对象,采用酶循环法进行Hcy检测。分别按性别、年龄、地理位置分组,运用SPSS 17.0软件进行描述性统计学分析。结果 49 818例高血压患者Hcy水平为(12.92±8.8)μmol/L,高Hcy血症总体患病率为64.46%。男性Hcy水平及高Hcy血症患病率均高于女性,差异有统计学意义(P<0.05);Hcy水平与年龄呈正相关(r=0.218,P<0.01),不同年龄组间高Hcy血症患病率差异有统计学意义(P<0.01),随年龄增大,患病率呈上升趋势;不同地区Hcy水平及高Hcy血症患病率差异有统计学意义(P<0.01)。结论鄞州区高血压人群Hcy水平与高Hcy血症患病率处于国内中等水平,存在性别、年龄和地区分布差异。西部地区为重点防控地区,男性老年高血压患者为高Hcy血症的重点防控对象,应做好干预措施。
Objective To analyze the prevalence of homocysteine (Hcy) and hyperhomocysteinemia in 49 818 hypertensive patients in Yinzhou District of Ningbo City, and to provide evidence for effective prevention and control strategies. Methods Hypertensive patients from January 2014 to December 2004 in Yinzhou District of Ningbo were enrolled in this study. Enzymatic cycling was used to detect Hcy. They were divided into groups by sex, age and geographical location, and SPSS 17.0 software was used for descriptive statistical analysis. Results The Hcy level of 49818 hypertensive patients was (12.92 ± 8.8) μmol / L, and the overall prevalence of hyperhomocysteinemia was 64.46%. The prevalence of Hcy and Hcy in males was higher than that in females (P <0.05). There was a positive correlation between Hcy and age (r = 0.218, P <0.01) The prevalence rate of disease was statistically significant (P <0.01). The prevalence increased with the increasing of age. The prevalence of Hcy and Hcy in different areas had statistical significance (P <0.01). Conclusion The prevalence of Hcy and Hcy in Yinzhou people with high blood pressure is in the middle level in China. There are differences in gender, age and geographical distribution. Western areas as a key prevention and control area, male elderly hypertensive patients with high risk of Hcy disease prevention and control targets, intervention measures should be done.