许多药物能干扰骨骼肌的正常结构和功能,引起种种损害。现简述如下: 一、急性横纹肌溶解症:如海洛英、美散痛、苯丙胺、苯环己哌啶、酒精、巴比妥类、5-氮胞甙、安定、眠尔通、异烟肼、二性霉素B、生胃酮、降糖灵、氟苯丙胺等能引起本症。这与药物的滥用或成瘾有关。表现肌肉疼痛,特别是近侧大肌群,伴肌肉肿胀和压痛。重者有弛缓性轻瘫和反射消失,血清肌酸磷酸激酶、乳酸脱氢酶常显著增加。且常发生肌红蛋白尿、急性肾功能衰竭与血清肌红蛋白增多有关。横纹肌溶解、合并血钾过低可引起致命的心律失常。治疗包括停药、严格卧床休 Many drugs can interfere with the normal structure and function of skeletal muscle, causing a variety of damage. Now summarized as follows: First, acute rhabdomyolysis: such as heroin, the United States pain, amphetamine, phencyclidine, alcohol, barbiturates, 5-azacytidine, stability, Hydrazine, amphotericin B, carbenoxolone, hypoglycemic, fenfluramine can cause this disease. This is related to drug abuse or addiction. Muscle pain is manifested, especially in the proximal big muscles, with muscle swelling and tenderness. Severe flaccid paralysis and reflex disappeared, serum creatine kinase, lactate dehydrogenase often increased significantly. And often myoglobinuria, acute renal failure and serum myoglobin increased. Rhabdomyolysis, combined with hypokalemia can cause fatal arrhythmia. Treatment includes withdrawal, strict bed rest