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目的 探讨门静脉高压性胃病 (PHG)与食管静脉曲张分度、肝硬化病因、幽门螺杆菌 (H·pylori)感染、门静脉主干与脾静脉宽度、血清一氧化氮 (NO)、内皮素 (ET)水平关系。方法 对住院确诊的 137例肝硬化患者进行胃镜和彩色B超检查 ,同时检测患者血清NO、ET水平。结果 PHG的发生率为 35 6 % ,PHG患者血清NO、ET显著高于无PHG肝硬化患者 (P <0 0 1) ,PHG的发生率及其严重程度与食管静脉曲张程度、门静脉主干和脾静脉内径成正比。在ChildA、B、C级肝功能之间、不同病因肝硬化之间、是否感染H·pylori之间PHG的发生率差异均无显著意义 (P >0 0 5 )。结论 PHG的发生与肝硬化病因、肝功能和H·pylori感染关系不明显 ;NO、ET参与了门脉高压形成与PHG的发生与发展的机制。
Objective To investigate the relationship between the incidence of portal hypertensive gastropathy (PHG) and esophageal varices, the etiology of liver cirrhosis, H. pylori infection, the width of portal vein and splenic vein, serum nitric oxide (NO), endothelin (ET) Horizontal relationship. Methods Gastroscopy and color B-ultrasound were performed in 137 hospitalized patients with cirrhosis and serum NO and ET levels were measured. Results The incidence of PHG was 35.6%. The serum levels of NO and ET in patients with PHG were significantly higher than those without PHG (P <0.01). The incidence and severity of PHG were correlated with the degree of esophageal varices, portal vein and spleen Intravenous diameter is proportional. There was no significant difference in the incidence of PHG between ChildA, B and C liver function, between cirrhosis and H. pylori infection (P> 0.05). Conclusions The occurrence of PHG is not related to the etiology of liver cirrhosis, liver function and H. pylori infection. NO and ET participate in the pathogenesis of portal hypertension and PHG.