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对过度滥用的老抗生素所衍生的新药物的临床应用,促使抗生素耐药问题日趋严重。不控制抗生素的使用而限制抗生素的耐药性的想法是不现实的。健康组织、制药公司和研究机构已开始意识到研发新靶标药物的紧迫性。有关细菌细胞分裂途径的丰富知识可以帮助人们寻找新型抑制剂,本文将讨论抑制细菌细胞分裂的治疗潜能,并回顾在这个抗生素发现新领域中的进展。
The clinical application of new drugs derived from overuse of old antibiotics has led to an increasingly serious problem of antibiotic resistance. The idea of not limiting the use of antibiotics to limit antibiotic resistance is not realistic. Health organizations, pharmaceutical companies and research institutions are beginning to realize the urgency of developing new target drugs. A wealth of knowledge about bacterial cell division pathways can help find new inhibitors. This article will discuss the therapeutic potential of inhibiting bacterial cell division and review the advances in this new field of antibiotic discovery.