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基底膜主要由胶原蛋白和非胶原蛋白组成，Ⅳ型胶原（Ｃｏｌｌａｇｅｎ Ⅳ，ＣＩＶ）是基底膜的核心胶原成分，层粘连蛋白（Ｌａｍｉｎｉｎ，ＬＮ）是广泛分布于基底膜的透明层，二者结合形成基底膜的骨架，是基底膜主要的组成蛋白。近年来的研究发现，基底膜蛋白与糖尿病（Ｄ
The basement membrane mainly consists of collagen and non-collagen. Collagen Ⅳ (CIV) is the core collagen component of the basement membrane. Laminin (LN) is a transparent layer widely distributed in the basement membrane. The formation of the basement membrane skeleton, the basement membrane is the main constituent protein. In recent years, studies have found that basement membrane protein and diabetes (D